The origin of chordates and the consequent genesis of vertebrates were major events in natural history. The amphioxus (lancelet) is now recognised as the closest extant relative to the stem chordate and is the only living invertebrate that retains a vertebrate‐like development and body plan through its lifespan, despite more than 500 million years of independent evolution from the stem vertebrate. The inspiring data coming from its recently sequenced genome confirms that amphioxus has a prototypical chordate genome with respect to (...) gene content and structure, and even chromosomal organisation. Pushed by joint efforts of amphioxus researchers, amphioxus is now entering a new era, namely its maturation as a laboratory model, through the availability of a large amount of molecular data and the advent of experimental manipulation of the embryo. These two facts may well serve to illuminate the hidden secrets of the genetic changes that generated, among other vertebrates, ourselves. (shrink)

Understanding how the chordate body plan originated and evolved is still controversial. The discovery by Spemann and Mangold in 1924 of the vertebrate organizer and its inductive properties in patterning the AP and DV axis was followed by a long gap until the 1960s when scientists started characterizing the molecular events responsible for such inductions. However, the evolutionary origin of the organizer itself remained obscure until very recently; did it appear together with the origin and radiation of vertebrates, or was (...) it a chordate affair? A recent study by Yu and collaborators,1 which analyses the expression of several organizer‐specific genes in amphioxus together with recent phylogenetic data that reversed the position of invertebrate extant chordates (e.g. urochordates and cephalochordates), indicates that the organizer probably appeared in early chordates. It likely had separate signalling centres generating BMP and Wnt signalling gradients along the DV and AP axis. The organizer was then lost in the urochordate lineage, most probably as an adaptation to a rapid and determinate development. BioEssays 29:619–624, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

The topology of DNA duplexes changes during replication and also after deproteinization in vitro. Here we describe these changes and then discuss for the first time how the distribution of superhelical stress affects the DNA topology of replication intermediates, taking into account the progression of replication forks. The high processivity of Topo IV to relax the left‐handed (+) supercoiling that transiently accumulates ahead of the forks is not essential, since DNA gyrase and swiveling of the forks cooperate with Topo IV (...) to accomplish this task in vivo. We conclude that despite Topo IV has a lower processivity to unlink the right‐handed (+) crossings of pre‐catenanes and fully replicated catenanes, this is indeed its main role in vivo. This would explain why in the absence of Topo IV replication goes‐on, but fully replicated sister duplexes remain heavily catenated. (shrink)

Alternative splicing (AS) is a widespread mechanism with an important role in increasing transcriptome and proteome diversity by generating multiple different products from the same gene. Evolutionary studies of AS have focused primarily on the conservation of alternatively spliced sequences or of the AS pattern of those sequences itself. Less is known about the evolution of the regulation of AS, but several studies, working from different perspectives, have recently made significant progress. Here, we categorize the different levels of AS evolution, (...) and summarize the studies on evolution of AS regulation, which point to a high level of evolutionary conservation of the regulation of AS events conserved between related species. This suggests that the quantitative regulation of AS is an intrinsic part of AS function. We discuss the potential role of changes in developmental regulation of AS as an additional layer in complex gene regulatory networks and in the emergence of genetic novelties. (shrink)

Attention-deficit hyperactivity disorder is one of the most common neurodevelopmental disorders in children and adolescents. People who have this disorder are characterized by presenting difficulties in the processes of sustained attention, being very active, and having poor control of their impulses. Despite the high prevalence of this disorder and the existence of various tests used for its diagnosis, few data are available regarding the usefulness and diagnostic validity of these tools. Given the difficulties that these subjects present in executive functions, (...) the aim of this study was to evaluate whether the Neuropsychological Assessment of Executive Functions battery for Children allows to establish specific profiles of executive performance for people with attention-deficit hyperactivity disorder. The sample was made up of 197 participants of both sexes, aged between 6 and 12 years age. A nonexperimental design was followed, using a comparative descriptive study method. The results indicated that the scales of phonological fluency, color path, rings, and interference are the most associated with the diagnosis of ADHD, providing data on inhibition, mental flexibility, sustained and selective attention, planning, verbal fluency, and working memory, among others. The practical implication of these results is in line with providing support in the clinical diagnosis that is carried out in children’s mental health units. In addition, the ENFEN tool can be valued as a suitable psychometric instrument in the psychoeducational field, helping professionals in a school environment to be more aware of the areas of cognitive development in which a student diagnosed with ADHD will have more difficulties and, in doing so, providing more adjusted and effective psychopedagogical measures when it comes to supporting students in their adaptation to the school environment. (shrink)

In this article, we will concentrate on the two true norm definitions that have existed throughout the history of the Deontic Logic: that offered by Professor Kalinowski and that proposed by the semantics of possible worlds. The former is based on Tarski’s definition of the true proposition, but it has the drawback of depending on a concrete, philosophical theory concerning the nature of norms. The latter, widely accepted nowadays, presents difficulties which we will analyse, using as a reference, K. Solt’s (...) critique. Despite its limitations, it offers the indisputable advantage of being independant of any concrete, philosophical option, and indicates, in our opinion, the correct way of proceeding. (shrink)

ObjectiveThis study aimed to analyze the influence and measurement of the relationship and interaction between the elderly lifestyles after the appearance of the SARS-CoV-2 variant and the factors analyzed comprised life satisfaction levels, social relationships, and daily-life activities.MethodsThe study population was ≥ 65 in Castile-La Mancha. The research design was quantitative and arose from primary data collected via an ad hoc survey carried out through the Computer Assisted Telephone Interview system by randomly stratified sampling. The sample size was made up (...) of 1,065 cases, and the participants were selected through a random sampling stratified by gender quotas, age, province, and habitat size.ResultsThe results obtained revealed two main lifestyles, from which a notable behavioral change in personal relationships led to infer toward alternative lifestyles.ConclusionNotwithstanding the variation in lifestyles of the elderly after the pandemic, certain relationships remained unaltered. Thus, from the analyzed variables, relatives and friends relationships were scarcely influenced by the supervened incident. (shrink)

La obtención de alimentos sanos y seguros requiere de técnicas de conservación inocuas para el consumidor y para el me­dio ambiente, entre las que se destaca la bioconservación. A su ca­tálogo de compuestos naturales o microorganismos, utilizados de forma habitual, la bioconservación ha incorporado recientemente los bacteriófagos y las proteínas fágicas con actividad lítica. La utilización de fagos y endolisinas en el biocontrol ofrece importantes ventajas frente a otros sistemas de conserva­ción tradicionales. Entre dichas ventajas destacan su inocuidad, especificidad y (...) versatilidad. Por otra parte, la acuciante necesidad de reducir el uso de antibióticos en la cadena alimentaria ha impul­sado la investigación basada en estos antimicrobianos con el fin de aplicarlos en producción primaria. Sin embargo, y a pesar de la gran eficacia ya demostrada en múltiples sectores, la falta de legislación de la Unión Europea sobre el uso de bacteriófa­gos junto con la necesidad de ser aceptados por los consumidores, son factores que están afectando negativamente a su implantación como bioconservantes. En este contexto, este artículo recoge los últimos resultados relacionados con este tipo de antimicrobianos en la industria agro-alimentaria, y resume los puntos clave para entender las posibilidades reales de su aplicación ante los nuevos requisitos asociados con una producción sostenible tanto desde una perspectiva económica como ambiental. (shrink)

In this writing it is presented Rawl’s proposal about the possibility of civil disobedience in the face of a democratic authority legitimately established. Rawlsian civil disobedience shows its antiauthoritarian claims depending on the maintenance of a fair order, and social society is the way of..

En el texto se llevan a cabo una serie de reflexiones en relación a la formación ética en las universidades para desde ahí edificar mejores ciudadanos. La relevancia de los estudios teóricos en la temática ética es crucial para apuntalar la comprensión de la ética y la ciudadanía en la vida práctica: sólo así podremos cambiar algo de este mundo. Además, la complejidad de nuestra realidad requiere de un pensar crítico para poder desbrozar tales complejidades, ayudándonos a comprender mejor nuestra (...) realidad y circunstancia. Sólo así podremos convertirnos en seres responsables de lo que nos toca hacer en nuestro mundo. La exigencia de un pensar ético crítico no puede dejarse de lado dado que será el único herramental que nos posibilite proyectarnos al futuro en la construcción de una mejor humanidad. (shrink)

En este texto se pretende mostrar la importante tarea que llevó a cabo Vico en torno a la diversidad de culturas, y la posibilidad de comprensión entre ellas, por medio del método hermenéutico que parte de la fantasía. Una apuesta por el pluralismo cultural y el entendimiento de los pueblos desde la categoría de lo (sentido) "común".

Although subsistence hunting is cross-culturally an activity led and practiced mostly by men, a rich body of literature shows that in many small-scale societies women also engage in hunting in varied and often inconspicuous ways. Using data collected among two contemporary forager-horticulturalist societies facing rapid change, we compare the technological and social characteristics of hunting trips led by women and men and analyze the specific socioeconomic characteristics that facilitate or constrain women’s engagement in hunting. Results from interviews on daily activities (...) with 121 Tsimane’ and 159 Baka show that Tsimane’ and Baka women participate in subsistence hunting, albeit using different techniques and in different social contexts than men. We also found differences in the individual and household socioeconomic profiles of Tsimane’ and Baka women who hunt and those who do not hunt. Moreover, the characteristics that differentiate hunter and non-hunter women vary from one society to the other, suggesting that gender roles in relation to hunting are fluid and likely to change, not only across societies, but also as societies change. (shrink)

The main objective of this work is to examine the prevalence of psychopathy in the general adult population from the main currently existing theoretical perspectives of psychopathy, using for this purpose the five-factor or Big Five model as a common language that allows the comparison and integration of the personality traits considered as defining psychopathy by these different perspectives. The NEO Personality Inventory-Revised was applied to a sample of 682 adults of the general Spanish population. The prevalence of clinical and (...) subclinical psychopathy was calculated according to six different definitions of these two constructs based on Hare’s, Lilienfeld’s, triarchic, and DSM-5-hybrid models, and the simultaneous presence of a minimum number of personality traits that differed from the sample mean by one standard deviation. Prevalence rates for the different definitions were consistently low, indicating that the prevalence of clinical psychopathy in the general Spanish population is around 0.55%, and that of subclinical psychopathy is around 1.65%. There were no significant sex differences in the prevalence of psychopathy. These results question the alarmist claims that warn about the existence in society of a very high number of people with psychopathy who can cause many social, economic, physical, and psychological damage to others. (shrink)

En la presente investigación se valoran las prácticas inclusivas de 6 1 docentes de educación básica de Colima, Sonora y San Luis Potosí adscritos a escuelas urbanas y rurales de México nominadas como exitosas. Se aplicaron varios instrumentos, como la GEPIA, la SACIE, el TEIP, el Cuestionario para Favorecer los Aprendizajes de Mitchell y el Protocolo C ODCA.

In the context of European Convergence, it has non-stop been encouraged a revolution in higher education in order to face up to challenges thrown down by the socalled "knowledge society". Nevertheless, as it happens in all revolutions, by means of the revolutionary legislation we risk destroying completely what we were trying to legislate on. This essay aims to attract academic circles attention to this matter so 225 LOGOS. Anales del Seminario de Metafísica ISSN: 1575-6866 Vol. 37 (2004): 225-253 Carlos Fernández (...) Liria La revolución educativa Luis Alegre Zahonero that, at least, this disaster is not consolidated with our collaboration. (shrink)

El timbre general de los documentos implicados en el actual proceso de reforma educativa oscila entre la apología y el tecnocratismo, permaneciendo a la sombra de la discusión, por lo que al ámbito académico respecta, las más de las veces, el papel que la Universidad jugará como motor de la investigación y la innovación tecnológica en la dinámica competitiva de los grandes bloques capitalistas. Estos textos deben ser leídos en su contexto social, político y económico, así como confrontados a la (...) luz, o más bien a la oscuridad, de documentos de la Comisión Europea relativos a las políticas de convergencia y competitividad económica. Las siguientes... líneas acotan con gran precisión el contexto de la reforma: "Los poderes públicos, para asumir sus responsabilidades deben apoyar el desarrollo de los mercados del futuro y prever los ajustes en vez de sufrirlos. La Unión Europea debe situar mejor su capital científico y tecnológico al servicio de la competitividad industrial y de las necesidades de los mercados. Conviene prestar mayor atención a la difusión de los resultados de la innovación, su transferencia y su valorización por la industria y actualizar la distinción tradicional entre investigación fundamental, investigación precompetitiva e investigación aplicada para evitar lo que ha ocurrido en algunas ocasiones en el sentido de que la industria europea no siempre ha podido beneficiarse de todos los esfuerzos efectuados en materia de investigación" 1. Según creemos, el actual proceso de convergencia persigue la conversión de la educación superior en una mera función de la reproducción capitalista. The general tone of documents that relate to the actual education reform process oscillates between self-defense and technocratism. In academic circles, far from debate, the university is regarded as being the engine of investigation and the innovative technology that will be employed by large capitalist groups in their fields of dynamic competition. These texts should be read in their social, political and economic contexts and should be compared with the clarity or perhaps obscurity of European Commission papers written on convergence and economic competitiveness. We believe that the present convergence process is designed to promote further education as a mere tool to be used in capitalist reproduction. (shrink)

José Luis Moreno argumenta contra lo que considera una variedad de formas de fetichismo político. Lo que tienen en común es depositar una confianza excesiva o monolítica en algún mecanismo democrático en particular. Compartimos su motivación y en esta nota crítica intentamos llevar sus argumentos más lejos preguntándonos si diferentes tipos de conocimiento políticamente relevante pueden distinguirse, si en algunos contextos es necesario dejar las decisiones en manos de expertos y si la propuesta de Moreno cae en un nuevo tipo (...) de fetichismo con respecto al sorteo como mecanismo capaz de eliminar injusticias sociales profundas. (shrink)

Although entrepreneurial intention has been widely studied using cognitive models, we still lack entrepreneurial vocation and, therefore, lack disruptive innovations. Entrepreneurship scholars have some understanding of the reasons underlying this weakness, although there is much room for improvement in our learning concerning how to promote entrepreneurship among university students, especially in the transformed context of digital technologies. This paper focuses on the early stages of start-up, and in particular seeks to evaluate what role social and psychological factors play in the (...) development of entrepreneurial intentions. Drawing on network theory, we consider the impact of social networks on entrepreneurial intention. Specifically, we analyze the influence of two types of social networks: face-to-face and online social networks, with the latter proving especially important in digital transformations. In addition, based on affective congruency theory, we relate affect with entrepreneurial intention. Particularly, we evaluate the influence of positive and negative dispositional affectivity on the formation of entrepreneurial intentions. Finally, since affect and emotions can also be related with social relationships, we analyze whether dispositional affectivities influence entrepreneurial intention through the mediation effect of social networks. Using structural equation modeling, we confirm the impact of both online and face-to-face social networks, as well as positive dispositional affectivity on entrepreneurial intention for 589 higher education students in Spain. However, negative dispositional affectivity is not seen to influence entrepreneurial intention. Furthermore, both face-to-face and online social networks are influenced by positive dispositional affectivity. Moreover, these two types of networks can even partially mediate the relationship between positive dispositional affectivity and entrepreneurial intention. Positive dispositional affectivity can thus influence entrepreneurial intention in two different ways: directly and indirectly through both face-to-face and online social networks. This study provides further insights and adds to the literature on affect, social networks, and entrepreneurial intention. From a broader perspective, we also contribute to the literature on disruptive innovations by explaining how the development of entrepreneurial intentions would have positive consequences for university students vis-à-vis achieving these disruptive innovations. (shrink)

The nurse-patient relationship involves complex attitudes and behaviours with ethical and deontological implications. It has been linked to improvements in patient health outcomes, although there is still no consensus in the scientific literature as to the definition and characterisation of the concept. This article aim to define the concept of the nurse-patient relationship. A concept analysis was conducted using the Walker and Avant method to identify the attributes defining the nurse-patient relationship. An integrative review of the literature was conducted using (...) the PubMed, Web of Science, Scopus, and Cumulative Index to Nursing & Allied Health Literature databases. A review of the grey literature and other minor non-indexed publications on the topic was also conducted. A total of 36 articles were included in the review. A model case, a contrary case, a related case, and empirical references were produced to clarify the concept and identify its essential attributes. The concept is defined as a helping relationship involving interaction between different players. It is the basis of nursing care and is intended to meet the healthcare needs of the individual receiving this care. It is also viewed as an intervention in itself, requiring a specific training process just like any other nursing skill. The essential attributes of the relationship are empathy, presence, contact, authenticity, trust, and reciprocity. In conclusion, the nurse-patient relationship is a helping relationship established with the patient and/or their family based on interaction, communication, respect for ethical values, acceptance, and empathy in order to encourage introspection and behavioural change. Key components include communication, active listening, and respect. Bioethical values and confidentiality must also be present to ensure that the relationship is built on equality and intimacy. (shrink)

The main purpose of this study was to analyze the presence and current situation of the game of skittles throughout the northern route of the Camino de Santiago. Thus, we considered its current practice, modalities, where it is played, and its different manifestations as an informal and formal game, comparing it with other traditional games on this pilgrimage route. To do this, a mixed qualitative-quantitative study was designed with 89 participants, constituting an informant for each municipality through which the Northern (...) Way passes. An ad hoc questionnaire was used for the data collection, which was processed through content analysis by expert judges and by using the IBM-SPSS statistical package. The results of the study show notable skittles activity on the Northern Camino, reflected in the number of skittles alleys, the number of clubs, associations, and peñas participating in federated leagues, and the wide range of varieties of skittles currently active on the Camino. The relationship between skittles and local culture, both symbols of identity in these northern Spanish regions, made it possible to preserve the traditional heritage in these places, keeping it alive today, despite the push toward new and more attractive leisure and sport trends. (shrink)

A growing number of recreational races are being held in different locations, drawing many local and visiting runners. This study examined the relationships between quality, value, satisfaction, and loyalty among runners in a recreational race and examines potential differences in relationships between these constructs based on the runners’ experience. The participants were 985 runners with a mean age of 40.74±9.41years. Validated, reliable ad hoc instruments were used. A multi-group analysis was performed to ascertain the existence of relationships between the constructs (...) and differences in the relationships between the different study groups. The results show that quality is a direct antecedent of value and satisfaction. Value is directly related to satisfaction and indirectly related to loyalty. Satisfaction is related to the loyalty of participants in the race. Differences in the relationship between satisfaction and loyalty were dependent upon the runners’ experience. Loyalty to a race depends primarily on satisfaction and is modified by the runners’ experience. (shrink)

This article analyzes the construction of female subjectivity in the specific context of audiovisual cyberspaces in Spain dedicated to the struggle against violence against women. Looking at the YouTube channels of two virtual feminist communities that deal with violence against women, the authors analyze how the victim-subject is configured in terms of agency and activism. The authors adopt a multimodal model of studying the sign complexes of the videos as semiotic artifacts that produce meaning. Sign complexes are always engaged because (...) representation is never neutral because what is represented in sign is meant to realize the values and positions of those who make the sign. In this article, the authors understand feminist activism in the fight against violence targeting women as constructing in its discourse not only the activist process, but also the subject of this activism: the victim-subject of gender-based violence. The analysis engages in the discussion about the various ways in which this subject is interpellated by the audiovisual texts in terms of agency. As a result, this study proposes the necessity to devise new ways of articulating this subject as a political and agential one. (shrink)

Es necesario enfocar escépticamente las pocas referencias a Pitágoras y los pitagóricos contenidas en los diálogos de Platón, pues resulta difícil tomar la medida efectiva de una influencia pitagórica sobre el ateniense. De hecho, las únicas referencias explícitas a Pitágoras (Rep. X 600a-b) y a los pitagóricos (Rep. VII 530c-531a) no nos dicen mucho y, respecto a los personajes tradicionalmente considerados pitagóricos, nuestra información es poco fiable, incierta y a veces contradictoria. Tal prudencia es particularmente útil en el caso de (...) Timeo y del personaje homónimo de este diálogo, cuyo pitagorismo, aunque ampliamente aceptado por los comentaristas, parece muy discutible. Así sólo la aplicación de un método histórico prudente y lúcido puede evitar esta deriva que identifica como pitagórico toda referencia a la transmigración del alma y las matemáticas en sentido amplio. (shrink)